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Table 2.4 QSAR Analyses of the Relative Toxicity of the Chlorophenols.

line

Using data on Daphnia magna.

Chlorophenol
congeners

24-h IC50 (mg/L)

Ratio of
CP/PCP

range

mean

2-MCP

16.6-19.3

17.95

23.62

3-MCP

13.8-17.75

15.78

20.76

4-MCP

5.79-10.34

8.07

10.62

2,3-DCP

4.09-6.30

5.19

6.83

2,4-DCP

2.48-2.89

2.68

3.53

2,5-DCP

-

4.50 *

5.92 *

2,6-DCP

8.69-10.08

9.38

12.34

3,4-DCP

2.55-2.98

2.77

3.64

3,5-DCP

1.85-2.33

2.09

2.75

2,3,4-TCP

2.00-2.48

2.24

2.95

2,3,5-TCP

2.06-2.50

2.28

3.00

2,3,6-TCP

6.25-8.52

7.38

9.71

2,4,5-TCP

1.88-2.29

2.08

2.74

2,4,6-TCP

4.93-6.01

5.47

7.20

3,4,5-TCP

0.82-0.93

0.88

1.16

2,3,4,5-TTCP

1.52-1.98

1.76

2.32

2,3,4,6-TTCP

-

2.70 *

3.55 *

2,3,5,6-TTCP

1.87-2.66

2.27

2.99

2,3,4,5,6-PCP

0.62-0.89

0.76

1.00

This is an experiment by Devillers and Chambon in 1986 (57). The Daphnia
magna were all >72 hours old. The water hardness was 200 mg/L as CaCO3,
dissolved oxygen >2.27 mg/L, pH 7.8 to 8.2 and the temperature 20C.
* 2,5-TCP and 2,3,4,6-TTCP were not tested; these two were estimated
using QSAR arguments.

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