Table 5.0 Cytotoxicity, Fetotoxicity/Embryotoxicity and Teratogenicity of the Chlorophenols.

line

congener	concentration or dose	refs.	species and effects
CYTOTOXICITY
4-MCP	250 mg/L	448 502 503	*Vicia faba* root cells had decreased mitotic index, anaphase bridges, cytomixis, lagging chromosomes, and disturbed meta- and ana-telophases
2,4-DCP	16.3 g/l	448 502 503	application as a spray to *Vicia faba* buds resulted in meiotic alterations of chromosome stickiness, lagging chromosomes and anaphase bridges
2,4-DCP	62.5 mg/L	448, 502 503	*Vicia faba* root cells developed meiotic alterations of chromosome stickiness, lagging chromosomes, anaphase bridges, chromosome disintegration, cytomixis, and disturbed prophase and anaphase.
PCP	174 ng/L, 87 ng/L 43.5 ng/L	448, 502 503	*Vicia faba* root cells developed a decreased mitotic index, anaphase bridges, cytomixis, lagging chromosomes, and disturbed meta- and ana-telophase
FETOTOXICITY/ EMBRYOTOXICITY
2,4,5-TCP	9.0 mg/kg	480	pregnant mice receiving oral doses during days 6-15 of gestation showed increased rates of resorption and embryo mortality.
2,3,4,6-TTCP	10 mg/kg/d	322	oral doses to female rats on day 21 of gestation had no effect
2,3,4,6-TTCP	30 mg/kg/d	322	oral doses to female rats on day 21 of gestation produced delayed ossification of skull bones in 17% of the young.
2,3,4,6-TTCP	25 mg/kg/d	531	there was no effect on female rats or their embryos.
2,3,4,6-TTCP	100-200 mg/kg/d	531	caused reduced maternal weight gain and 3-4% pre-implantation losses

congener	concentration or dose	refs.	species and effects
2,3,4,5,6 -PCP	26-30 mg/kg	38 244, 288 322	causes reduced numbers of offspring, neonatal survival rates and weanling growth rates in rats
2,3,4,5,6 -PCP	30 mg/kg/d	737 738	NOAEL for rabbit and rat embryos
2,3,4,5,6 -PCP	0.34-60 mg/kg	558, 564 565 566 567	causes fetotoxicty and maternal toxicity in rats, mice and hamsters
2,3,4,5,6 -PCP	80 mg/kg/d	738	caused resorptions, reduced live litter size and fetal body weights and malformations (gastroschisis, hydrocephaly, diagramatic hernia, kidney dilation, extra rib pairs, delayed ossification) in rats
TERATOGENICITY
2,4,5-TCP	9.0 mg/kg	480	oral doses at days 6-15 of gestation in mice does not lead to any observed teratogenic effects.
PCP	30 mg/kg/d	737 738	NOAEL for oral doses during days 6 to 18 of gestation in rabbits and days 6 to 15 of gestation in rats.
PCP	30 mg/kg/d	227 288	given 2 months prior to and right through to lactation causes no teratogenic effects.