Table 5.6 Ames Mutagenicity Assays using Salmonella typhimurium

line

(strains TA98, TA100, TA1535, TA1537 and TA1538)

chlorophenol congener		µg/plate of the chlorophenol
chlorophenol congener	***	0.1	0.5	1.0	5.0	50	100	200	500	1000
4-MCP								neg. **
2,3-DCP	neg.
2,4-DCP			neg.		neg.	neg.			neg. *
2,5-DCP			neg.		neg.	neg.			neg. *
2,6-DCP			neg.		neg.	neg.			neg. *
3,4-DCP			neg.		neg.	neg.			neg. *
3,5-DCP			neg.		neg.	neg.			neg. *
2,3,4-TCP		neg.		neg.			neg.			neg.
2,3,5-TCP		neg.	neg.	neg.	neg.	neg.	neg.		neg.	neg.
2,3,6-TCP	neg.
2,4,5-TCP			neg.		neg.	neg.			neg. *
2,4,6-TCP		neg.	neg.	neg.	neg.	neg.	neg.		neg. *	neg.
2,3,4,6-TTCP			neg.		neg.	neg.			neg. *
2,3,4,5,6-PCP	neg.

* toxic but not mutagenic. ** slight increase in only one strain. *** 2,3-DCP, 2,3,6-TCP and PCP are reported as negative in the Ames mutagenicity test but no details of the concentrations used are available to put into this table. PCP was also negative to all Salmonella stains at up to 10 mg/plate and E. coli negative to PCP at up to 5 mg/plate.