Table 7.5.1 The Effects of Pentachlorophenol on Mammals

line

mg/L	Species	Conditions	Effect	Ref.
		total quantity is unknown
12.5	man	oral and dermal, daily	EC	545
51	calf	Ca salt in drinking water	5-wk EC	167
60	calf	Na salt in drinking water	7-wk EC	167
106.5	man	dermal application, hands	2h.EC	545
1325	cows	oral in kerosene	LC₁₀₀	661
10000	man	dermal application	EC	162
mg dose	Species	Conditions	Effects	Ref.
4	monkey	rhesus, Na salt	NOEL	167
10	dog	daily in diet	4-mon LD₀	162
3200	calf	in 40 gallons of water	4-d NOEL	167
18000	man	70 kg	LD₁₀₀	163
	rats
10	daily in diet		4 mon LD₀	162
20	injection, causes temperature rise		1.5-2.0C	544
	rabbits
22-23	intravenous		1.5-h LD₁₀₀	541
40-50	dermal in pine oil		9-h LD₁₀₀	541
60-70	dermal in fuel oil		1.5-h LD₁₀₀	541
70-85	subcutaneous in olive oil		3-h LD₁₀₀	541
70-90	oral in fuel oil		2-h LD₁₀₀	541
90-100	dermal in fuel oil		1.5-h LD₁₀₀	541
100	subcutaneous		7-h LD₁₀₀	541
100-130	oral in olive oil		10-h LD₁₀₀	541
110-130	dermal in Dione oil		5-h LD₁₀₀	541
130-170	dermal in fuel oil		6-h LD₁₀₀	541
250	dermal		3-h LD₁₀₀	541
250-300	oral		3-h LD₁₀₀	541
350	dermal in olive oil		LD₁₀₀	654

Table 7.5.1 (continued)

mg/kg	Species	Conditions	Effect	Ref.
3.5	dog	chronic, oral, capsules	NOEL	752
27-210	many Sp.	oral, solvent & purity vary	LD₅₀	199
35-50	calves		11-d LD₅₀	323
140	calf	oral	LD₅₀	655
100	guinea pig	oral	LD₅₀	287
120	sheep	oral	LD₅₀	655
150-200	dog	oral	LD₅₀	287
168	hamsters	Syrian, both sexes, oral	LD₅₀	543
257	man	oral	LD₁₀₀	163
294	gerbils	female, oral in PPG	LD₅₀	450

mg/kg	Conditions		Effect	Ref.
	rats
0.34	reproduction study		NOEL	558
0.4	tech. grade, reproduction study, ovum implantation		LD₂₀	558
3	reproductive study		NOEL	199
3	daily, reproductive study		NOEL	38
3	oral, daily, pre- and post-mating		62-d NOEL	539
3.4	reprod. study, 12 % pup loss in 1st 2 weeks		LD12	558
4	tech. grade, reprod. study, fetal weight loss		EC	558
5	pregnant female, oral in corn oil, daily		NOEL	288
5	female, fetal effects study		NOEL	199
15	pregnant female, oral in corn oil, daily		EC	288
25	growth and blood effects study		NOEL	287
27	oral		LD₅₀	225
27	oral in fuel oil		3-h LD₅₀	541
27.3	oral in fuel oil		LD₅₀	542
27-210	solvent dependent, least in water		LD₅₀	199
30	daily, 1 generation reproduction study		EC	38
30	oral, daily, pre- and post-mating, fewer pups		62-d EC	539
30	pregnant, oral in corn oil, daily, weight loss		EC	288
34	rats, reproductive study 20% pup weight loss		LD13	558
40	tech. grade, reprod. study, 20% fetal wt. loss		EC	558
50	pregnant, oral in corn oil, daily weight loss		fetal LD₁₀₀	288
50-350	females more sensitive than males		LD₅₀	232
50-350	females more sensitive than males		LD₅₀	315
56	male, intraperitoneal		LD₅₀	652
65	oral at 3-4 days old		LD₅₀	539
66	Na salt given subcutaneously		2-h LD₅₀	541

Table 7.5.1 (continued)

mg/kg	Conditions	Effect	Ref.
77.9	oral in olive oil	LD₅₀	592
78	oral in olive oil	3-h LD₅₀	541
78	oral	LD₅₀	162
78	oral	LD₅₀	165
78	oral	LD₅₀	166
90	subcutaneous	LD₅₀	541
135	female, commercial grade	LD₅₀	288
135	female, oral	LD₅₀	526
146	male,	LD₅₀	540
146	oral	LD₅₀	161
150	adults, oral	LD₅₀	539
175	female	LD₅₀	540
205	male, commercial grade	LD₅₀	288
205	male, oral	LD₅₀	526
210	Na salt orally	2-h LD₅₀	541
250-300	oral	LD₅₀	541
276	intraperitoneal	LD₅₀	229
320	adult males, oral, tech. grade in pine oil	LD₅₀	540
330	females, oral, tech. grade in pine oil	LD₅₀	540

	mice (female C57, except for Ref. 287)
32	oral in 40% ethanol	LD₅₀	450
36	oral in 40% ethanol	LD₅₀	450
59	intraperitoneal in propylene glycol	LD₅₀	450
74	oral in 40% ethanol	LD₅₀	450
120-140	oral	LD₅₀	287
150	oral in propylene glycol	LD₅₀	450