Table 7.5.2 The Effects of Chlorophenols on Mammals and Birds

line

mg/kg	Species	Conditions	Effect	Ref.
		2-MCP
120	rabbit	intravenous, minimum dose	LD	364
230	male rat	intraperitoneal	LD₅₀	229
230	rat	intraperitoneal, minimum dose	LD	364
440	blue fox		LD₅₀	364
670	rat	oral	LD₅₀	364
800	guinea pig	subcutaneous, minimum dose	LD	364
950	rat	subcutaneous	LD₅₀	364
950	rabbit	subcutaneous	LD₅₀	364
2230	rat	oral in olive oil	LD₅₀	652
3160	male rat	subcutaneous	LD₅₀	652
		3-MCP
335	male rat	intraperitoneal	LD₅₀	372
335	male rat	intraperitoneal	LD₅₀	229
697	rat	oral in olive oil	LD₅₀	372
1730	rat	subcutaneous	LD₅₀	372
1865	male rat	oral in olive oil	LD₅₀	652
4630	male rat	subcutaneous in olive oil	LD₅₀	652
		4-MCP
250	rat	intraperitoneal	LD₅₀	372
281	rat	intraperitoneal	LD₅₀	229
500	rat	oral	LD₅₀	372
500	rat	oral	LD₅₀	653
660	rat	oral in olive oil	LD₅₀	372
660	rat	oral in olive oil	LD₅₀	652
860	mouse	oral	LD₅₀	372
1030	rat	subcutaneous in olive oil	LD₅₀	372
1030	rat	subcutaneous in olive oil	LD₅₀	652
1500	rat	dermal	LD₅₀	372
1500	rat	dermal	LD₅₀	653
		MCPs
250	rats		LD₅₀	315
250	rats		LD₅₀	232

Table 7.5.2 (continued)

mg/kg	Species	Conditions	Effect	Ref.
		2,4-DCP
9	sheep and cattle	muscle and fat tissue levels	28-d NOEL	315
9	sheep and cattle	liver and kidney tissue levels	28-d EC-high	315
30	sheep and cattle	muscle and fat tissue levels	28-d NOEL	315
30	sheep and cattle	liver and kidney tissue levels	28-d EC-high	315
45	mouse	oral, daily	6-mon NOEL	312
60	sheep and cattle	muscle and fat tissue levels	28-d NOEL	315
60	sheep and cattle	liver and kidney tissue levels	28-d EC-high	315
100	mouse	oral, daily	6-mon NOEL	312
150	pigeons	oral; 91% eliminated in 5 days	not lethal	497
230	mouse	oral, daily	6-mon EC	312
430	rat	intraperitoneal	LD₅₀	229
1600	mouse	oral	LD₅₀	312
1630	mice, both sexes	oral	LD₅₀	312
1720	rat	in fuel oil	LD₅₀	652
1730	rat	subcutaneous	LD₅₀	496
3670	male rat	oral	LD₅₀	312
4500	female rat	oral	LD₅₀	312
		2,6-DCP
5.5	rat livers	mitochondrial enzymes	EC50	425
390	rat	intraperitoneal	LD₅₀	372
390	male rat	intraperitoneal	LD₅₀	229
1730	rat	subcutaneous	LD₅₀	426
2940	rat	oral	LD₅₀	426
		DCPs
250	rats		LD₅₀	315
250	rats		LD₅₀	232
		2,3,6-TCP
308	male rat	intraperitoneal	LD₅₀	229
		2,4,5-TCP
1	rabbit	oral, 20 doses in 28 days	28-d NOEL	313
1	rats, both sexes	oral	98-d NOEL	313
1	man	oral, urine and fecal residue levels	NOEL	489

Table 7.5.2 (continued)

mg/kg	Species	Conditions	Effect	Ref.
3	rats, both sexes	oral	98-d NOEL	313
10	rabbit	oral, 20 doses in 28 days	28-d NOEL	313
10	rats, both sexes	oral	98-d NOEL	313
10	cows	dietary level; milk and cream residue levels	3-wk <0.05 mg/kg	464
30	cows	dietary level; milk and cream residue levels	3-wk <0.05 mg/kg	464
30	rat	oral,18 doses in 24 days	24-d NOEL	313
30	rat	oral, daily,	17-wk NOEL	478
30	rats, both sexes	oral	98-d EC	313
100	rat	oral,18 doses in 24 days	24-d NOEL	313
100	rabbit	oral, 20 doses in 28 days	28-d EC	313
100	rats, both sexes	oral	98-d EC	313
300	rat	oral,18 doses in 24 days	24-d NOEL	313
355	male rat	intraperitoneal	LD₅₀	229
500	rabbit	oral, 20 doses in 28 days	28-d EC	313
820	rat	oral in fuel oil	LD₅₀	652
1000	cows	dietary level; 3 week; milk residues	0.24 mg/kg	464
1000	cows	dietary level; 3 week; cream residues	0.19 mg/kg	464
1000	rat	oral,18 doses in 24 days	24-d EC	313
1000	rat	oral, daily,	17-wk EC	478
2260	rat	subcutaneous in fuel oil	LD₅₀	652
2520	male rat	oral	LD40	313
2800	rat	oral	LD₅₀	476
2960	rat	oral	LD₅₀	313
2960	male rat	oral	LD₅₀	313
3000	rat	oral	LD₅₀	464
3160	male rat	oral	LD40	313
3980	male rat	oral	LD100	313
4000	rat	oral	LD₅₀	475
		2,4,6-TCP
276	male rat	intraperitoneal	LD₅₀	229
		3,4,5-TCP
372	male rat	intraperitoneal	LD₅₀	229
372	male rat	intraperitoneal	LD₅₀	418

Table 7.5.2 (continued)

mg/kg	Species	Conditions	Effect	Ref.
		TCPs
250	rats		LD₅₀	315
250	rats		LD₅₀	232
		2,3,4,5-TTCP
97	female mice	intraperitoneal in 40% ethanol	LD₅₀	450
133	female mice	intraperitoneal in prop. glycol	LD₅₀	450
400	female mice	oral in 40% ethanol	LD₅₀	450
499	rats	intraperitoneal	EC	520
533	female gerbils	oral in propylene glycol	LD₅₀	450
572	male mice	oral in 40% ethanol	LD₅₀	450
677	female mice	oral in propylene glycol	LD₅₀	450
1507	rats	intraperitoneal	EC	520
2000	rats, both sexes	dermal in ethanol to 8 cm2 area	<14-d LD₅₀	106
		2,3,4,6-TTCP
10	male rats	oral in olive oil	55-d NOEL	324
50	male rats	oral in olive oil	55-d NOEL	324
82	female mice	intraperitoneal in prop. glycol	LD₅₀	450
100	male rats	oral in olive oil	55-d EC	324
121	female mice	intraperitoneal in 40% ethanol	LD₅₀	450
130	male rats	intraperitoneal in olive oil	LD₅₀	229
131	female mice	oral in 40% ethanol	LD₅₀	450
163	male mice	oral in 40% ethanol	LD₅₀	450
300	male rats	oral in olive oil	24-h NOEL	324
360	male rats	oral in olive oil	24-h NOEL	324
410	male rats	oral in olive oil	24-h NOEL	324
432	male rats	oral in olive oil	24-h EC	324
518	male rats	oral in olive oil	24-h EC	324
632	male rats	oral in olive oil	24-h EC	324
698	female gerbils	oral in propylene glycol	LD₅₀	450
735	female mice	oral in propylene glycol	LD₅₀	450
		2,3,5,6-TTCP
48	female mice	intraperitoneal in 40% ethanol	LD₅₀	450
89	male mice	oral in 40% ethanol	LD₅₀	450
109	female mice	oral in 40% ethanol	LD₅₀	450
109	female mice	intraperitoneal in prop. glycol	LD₅₀	450
543	female mice	oral in propylene glycol	LD₅₀	450
979	female gerbils	oral in propylene glycol	LD₅₀	450