Voyer et al. noted, in 1982, that silver reduced cadmium toxicity in an acute test with embryos of the winter flounder, Pseudopleuronectes americanus, exposed to mixtures of cadmium and silver. In contrast, the clam, Mercenaria mercenaria, exposed to cadmium in the diet showed reduced uptake of silver into the kidney and digestive gland (Robinson et al. 1985). Similarly, Chou et al. in 1987 observed that addition of cadmium to the diet of the American lobster, Homarus americanus, decreased uptake of silver in the digestive gland, disrupting a significant relationship between the levels of copper and silver that were otherwise present.
Several studies have also indicated a relationship between copper and silver levels. In 1981, Coglianese and Martin showed that the toxicity of silver was increased by low levels of copper. In 1981 Chou et al. noted that an increase of copper in the diet of Homarus americanus resulted in an increased uptake of silver. In contrast, Nelson et al. in 1983 observed that copper and silver levels in the marine snail, Crepidula fornica, increased together until a critical point, at which time the levels of silver dropped off while the levels of copper in the tissues continued to increase. Similarly in 1976, Luoma and Jenne noted that high ambient copper levels decreased silver uptake in the polychaete, S. plana. Zinc uptake was observed to decrease as silver uptake increased (Davies and Goettl 1978).